Management of dengue haemorrhagic fever (DHF)

A novel dengue fever (DF) and dengue haemorrhagic fever (DHF) analysis using artificial neural network (ANN)

Dengue fever (DF) is an acute febrile viral disease frequently presented with headache, bone or joint and muscular pains, and rash. A significant percentage of DF patients develop a more severe form of disease, known as dengue haemorrhagic fever (DHF). DHF is the complication of DF. The main pathophysiology of DHF is the development of plasma leakage from the capillary, resulting in haemoconcen...

Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever-dengue shock syndrome (DHF/DSS).

The past four decades has witnessed a consolidation of the original observations made in the 1970s that dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) have an immunological basis. Following reinfection with a dengue virus of different serotype, severe disease is linked to high levels of antibody-enhanced viral replication early in illness which is followed by a cascade of memor...

Dengue haemorrhagic fever

Factors increasing the risk of DHF outbreaks The occurrence of DHF outbreaks is linked to a number of factors, including the density of mosquito vectors, particularly that of Aedes aegypti. The precise population density of Ae. aegypti that is needed to sustain dengue virus transmission epidemically or endemically has yet to be determined, but experience in Singapore in recent years suggests th...

Dengue haemorrhagic fever

The two basic methods for establishing a laboratory diagnosis of dengue infection are detection of the virus (e.g. culture) or detection of anti-dengue antibodies (serology). Until recently, detection of the virus implied solely the recovery of the virus by culture; however, current procedures can detect dengue virus RNA and specific dengue virus antigens. Consequently, these procedures are lik...

Dengue haemorrhagic fever